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ChemicalBook--->CAS DataBase List--->101001-34-7

101001-34-7

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    101001-34-7 Structure

    101001-34-7 Structure
    IdentificationBack Directory
    [Name]

    KB 3022
    [CAS]

    101001-34-7
    [Synonyms]

    KB 3022
    KBT-3022
    KB3022 (KBT3022
    ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate
    ethyl 2-(2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1H-pyrrol-1-yl)acetate
    2-[4,5-Bis(4-methoxyphenyl)thiazol-2-yl]-1H-pyrrole-1-acetic acid ethyl ester
    1H-Pyrrole-1-acetic acid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester
    [Molecular Formula]

    C25H24N2O4S
    [MOL File]

    101001-34-7.mol
    [Molecular Weight]

    448.53
    Chemical PropertiesBack Directory
    [Melting point ]

    132.5-135.5°
    [Boiling point ]

    600.3±65.0 °C(Predicted)
    [density ]

    1.22±0.1 g/cm3(Predicted)
    [storage temp. ]

    Sealed in dry,2-8°C
    [solubility ]

    DMF:10.0(Max Conc. mg/mL);22.0(Max Conc. mM)
    DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
    DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
    [form ]

    A crystalline solid
    [pka]

    2.68±0.10(Predicted)
    [color ]

    Off-white to pink
    Safety DataBack Directory
    [Symbol(GHS) ]


    GHS07
    [Signal word ]

    Warning
    [Hazard statements ]

    H302-H315-H319-H335
    [Precautionary statements ]

    P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
    [Toxicity]

    LD50 orally in male mice: >3000 mg/kg (Yoshino)
    Spectrum DetailBack Directory
    [Spectrum Detail]

    KB 3022(101001-34-7)1HNMR
    Hazard InformationBack Directory
    [Biological Activity]

    Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregation properties.
    [in vitro]

    KB 3022 is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. It also has potential in both prophylaxis and treatment of ischemic brain injury.
    [target]

    TargetValue
    COX
    ()
    [storage]

    Store at -20°C
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