| Identification | Back Directory | [Name]
THPN | [CAS]
100079-26-3 | [Synonyms]
THPN
THPN >=98% (HPLC)
1-(3,4,5-Trihydroxyphenyl)-1-nonanone
1-Nonanone, 1-(3,4,5-trihydroxyphenyl)- | [Molecular Formula]
C15H22O4 | [MDL Number]
MFCD31656702 | [MOL File]
100079-26-3.mol | [Molecular Weight]
266.33 |
| Hazard Information | Back Directory | [Uses]
THPN is a Nur77 agonist. THPN binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines. | [General Description]
THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B. | [Biochem/physiol Actions]
THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model. |
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